Asymmetric maxillary expansion is one of the unfavorable expansion outcomes that may present with esthetic and functional occlusal compromises that may be challenging to resolve. According to the literature this complication may develop with surgical and non-surgical expansion protocols. Evidence on the potential risks for asymmetric expansion is limited. We have yet to answer the questions why it happens and whether it can be prevented. In this presentation we will review the anatomy of asymmetric expansion with CBCT imaging and how to detect it early. We will discuss how it can be managed once it occurs and possible ways to minimize it.